The study examined the effects of Road Traffic Accidents on Economic security in Uganda using Jinja Road Police Division in Kampala Metropolitan Police East. The objectives of the study were to; examine the effects of fatal road traffic accidents on economic security; assess the effect of serious road traffic accidents on economic security; and determine the effect of minor road traffic accidents on economic security in Jinja Road Police Division. The study adopted a correlational research design and employed both quantitative and qualitative approaches for data collection and analysis. Simple random, purposive sampling and convenience sampling techniques were employed to select a sample of 112 from a target population of 125. A self- administered questionnaire and interviews were used to collect data. The study registered a response rate of 80.0% (93 out of 112). Quantitative data was analysed using descriptive and inferential statistics with SPSS Ver.27, while qualitative data was analysed through thematic approach by categorizing data into themes which enhanced effective interpretation of results. The key findings from the study revealed that there is a statistically negative and significant relationship between fatal road traffic accidents and economic security (r = -0.382**, p = 0.000, n= 87). Additionally, the study found out that there is a statistically negative and significant relationship between serious road traffic accidents and economic security (r = -0.475**, p = 0.000, n= 87). The study also found out that there is a statistically negative and significant relationship between minor road traffic accidents and economic security (r = -0.441**, p = 0.000, n= 87). It was concluded that fatal road traffic accidents significantly affect economic security in Uganda in terms of loss of human capital, increased healthcare costs and reduced quality of life or well-being of individuals as it reduces household incomes. The study concluded that the increase in serious road traffic accidents has a multifaceted impact on economic security, affecting individual employment, economic productivity and overall living conditions that perpetuate poverty. The study further concluded that due to minor accidents, households face financial challenges due loss of assets and property, repairs and replacement costs and potential disruptions to income, leading to a decline in economic security of individuals. The study recommended that the administration of Jinja Road Police Division, specifically the department of Traffic should implement educational programs to raise awareness about the importance of safe driving practices. That the Ministry of works and transport should work with local leaders within Jinja Road Police Division in Kampala Metropolitan Police East to identify, address high-risk road sections, intersections or areas prone to Road Traffic accidents and improve road signage, visibility and lighting to enhance overall road safety. The study further recommended that the administration of Jinja Road Police Division; Kampala Metropolitan Police East should foster partnerships with local communities to promote responsible driving behaviour and reporting of unsafe road conditions to avoid and/or reduce RTA.