Logistics management plays a vital role in the promotion of operational performance of organizations since it optimizes service and supplies quality, quantity, cost, place, and time to recipients (Kabale et al, 2019). In the nongovernmental organisations spectrum, the ability of logistics management to deliver improvements in cycle-times, inventory turnover, and reliability of operations which affect stakeholder satisfaction (Azim et al, 2015), cannot be underestimated. The study set out to examine the influence of logistics management and operational performance of nongovernmental organisations in South Sudan with a case study of The Rescue Initiative, Kajo Keji.It sought to examine the influence of procurement processes, material handling practices, and healthcare logistics practices on the operational performance of The Rescue Initiative, Kajo Keji. The study was grounded on the stakeholder theory propounded by Freeman (1984) and the resource – based view theory (RBV) by Peteraf (1993), the study adopted a post-positivist and phenomenological approach, a cross sectional survey and case study strategy using both quantitative and qualitative methods. The study population was 167, out of which a sample of 127 was used with the response rate at 77.9% that is, 99 respondents. The survey, interview, and document review methods were used to collect data involving the use of self-administered questionnaires, interview guides, and document review checklists as data collection instruments respectively. The study concluded that there is a strong positive relationship between logistics management and operational performance of The Rescue Initiative. With a low percentage variance of 18.10% based on the F value of 18.105, the 0.633 regression coefficient for procurement processes, materials handling practices, and health care logistics practices and operational performance of Rescue Initiative and a Sig. value of 0.000 less than 0.01 (p < 0.01), produced accurate results of predicting the degree of influence existing between them led to the rejection of the null hypothesis Ho: Logistics management has no significant influence on operational performance of The Rescue Initiative – Kajo Keji was rejected and the alternative H1: Logistics management has a significant influence on operational performance of The Rescue Initiative – Kajo Kejiwas adopted. The study recommends the adaption of more transparent negotiations such that the objectives by negotiating including; on-time performance, quality, reduced cost, and compliance in the operations of The Initiative are not compromised. Also, there is dire need to significant comply with the requirement to train staff in standards and practices applicable to the operation of equipment

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