The paper examined the organizational factors that informed decisions to adopt cloud computing by Small and Medium Enterprises (SMEs) in Kampala, Uganda. The paper is an outcome of a study conducted in Kampala in 2022. The study was both descriptive and explanatory and relied on the quantitative approach of data collection and analysis. The data were collected from 416 SMEs. It was found out that the benefits of cloud computing (Mean = 3.68, St. Dev = .773), the relevance of cloud computing to the organization (Mean = 3.58, St. Dev = .649), unreliability of insourced IT services (Mean = 3.74, St. Dev = .916), the need to backup organizational data (Mean = 3.87, St. Dev = .696)., managerial support for cloud computing (Mean = 3.29, St. Dev = .900), among others—drove decisions in organizations to adopt cloud computing.